肠道肿瘤类器官的研讨与使用

版块：机械制造类型：普通作者：化工产业技术分享查看：81 回复：0 获赞：0 时间：2022-05-18 18:57:52

ONCOGENESIS|肠道肿瘤类器官的使用研讨

类器官（Organoids）

类器官是一项立异性较高的研讨技能，近几年来遭到科研人士的追捧和广泛好评。现在，咱们国家在方针层面也给予了大力地支撑。2021年科技部发布的“十四五”国家要点研制方案“干细胞研讨与器官修正”要点专项中也特别说到疾病类器官模型。

什么是类器官（Organoids）？

类器官归于三维（3D）细胞培育物，包含其代表器官的一些要害特性。类体外培育体系包含一个自我更新干细胞群，可分解为多个器官特异性的细胞类型，与对应的器官具有相似的空间安排并能够重现对应器官的部分功用，然后供给一个高度生理相关体系。成体干细胞的安排样本、单一成体干细胞或许经过多能干细胞的定向诱导分解都能够发生类器官。而细胞系异质性差，遗传信息丢掉，无法模仿安排器官体内的三维结构‍；动物模‍型具有建模周期长，本钱高级问题。

640 (1).png

类器官的使用远景

‍‍‍‍‍2013年，类器官技能被Science誉‍为10 大科技发展，2017年，又被Nature Methods评为生命科学范畴的年度技能。类器官技能具有极高的立异性，近年来一直是研讨热门，到现在为止已获得多项严重研讨范畴的打破‍，但其使用研讨现在仍然处于起步阶段，其作为一种东西，在广泛的使用研讨方面潜力巨大，包含发育生‍物学、疾病病理学、细胞生物学、再生机制、精准医疗以及药物毒性和药效实验。关于这些使用以及其他使用，类器官培育‍完成了对现有2D培育办法和动物模型体系的高信息量的互补。此外，经过类器官繁衍的干细胞群替代受损或许患病的安排，类器官供给自体和同种异体细胞疗法的可行性，未来这一技能在再生医学范畴也具有巨大的潜力。‍‍‍‍‍‍

研讨思路共享

2022 年 1 月 19 日，由诺丁汉大学医学院癌症遗传学和干细胞组Abdolrahman S. Nateri教授团队在ONCOGENESIS(影响因子7.485)宣布了新研讨成果，题为《Anti-miR-135/SPOCK1 axis antagonizes the inflfluence ofmetabolism on drug response in intestinal/ colon tumourorganoids》。

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padding: 13px 1em 6px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; letter-spacing: 1.5px; color: rgb(94, 177, 132); background: rgb(240, 250, 246); text-align: center;"><p style="margin: 0px 5px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; clear: both; min-height: 1em; vertical-align: inherit;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 18px; text-align: justify;">ONCOGENESIS|肠道肿瘤类器官的使用研讨</strong></p><p style="margin: 0px 5px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; clear: both; min-height: 1em; vertical-align: inherit;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 51, 51); font-size: 18px; text-align: justify;"><br /></strong></p></section></section><section hm_fix="356:670" style="margin: -38px 0px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: flex-end;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 40px;"></section></section></section></section></section><p></p><section data-id="102702" data-tools="135编辑器" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, " helvetica="" sans="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" background-image:="" mmbiz.qpic.cn="" mmbiz_gif="" oirzt7ctxrnawwnlmkahx0eo9lf0tll2ebp4u1nailsyjrllgo3h3eox1vbuxbwzu6zys4cfje27bx6hw30hrg="" background-repeat:="" background-size:="" overflow-wrap:="" break-word=""><section style="margin: 10px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: space-between; align-items: flex-end;"><section style="margin: 0px 0px 0px 2px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 40px;"></section><section style="margin: 0px 2px -10px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 17px;"></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(120, 203, 150);"><section data-brushtype="text" hm_fix="351:883" style="margin: 0px; padding: 4px 2em; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(240, 250, 246); font-size: 16px; color: rgb(51, 159, 101); letter-spacing: 1.5px; line-height: 2em;"><h4 style="margin: 0px 5px; padding: 0px; outline: 0px; font-weight: 400; max-width: 100%; color: rgb(51, 51, 51); text-align: justify; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 18px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(51, 159, 101); text-decoration-style: solid; text-decoration-color: rgb(51, 159, 101); font-family: 微软雅黑, " microsoft="">类器官（Organoids）</span></strong></span></h4></section></section></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, " helvetica="" sans="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" background-image:="" mmbiz.qpic.cn="" mmbiz_jpg="" oirzt7ctxrnawwnlmkahx0eo9lf0tll2jqazln7qra7pbyvciab3eouvo9w43cehxzrjsuehssiib5vey8hocnuq="" background-repeat:="" background-size:="" overflow-wrap:="" break-word=""><p style="margin-right: 5px; margin-left: 5px; padding: 12px 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; vertical-align: inherit; line-height: 1.58824em; text-indent: 2em; font-family: 微软雅黑; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 16px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;">类器官是一项立异性较高的研讨技能，近几年来遭到科研人士的追捧和广泛好评。现在，咱们国家在方针层面也给予了大力地支撑。2021年科技部发布的“十四五”国家要点研制方案“干细胞研讨与器官修正”要点专项中也特别说到<strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="font-size: 16px; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; color: rgb(0, 176, 80);">疾病类器官模型</span></strong>。</time></span></time></p><p style="text-align: center"><img style="max-width:800px;max-height:300%;" src="uploadfiles/images/1429/20220518/185751_LQRUYI.png" title="640.png" alt="640.png" /></p><h4 style="margin: 5px; padding: 0px; outline: 0px; font-weight: 400; font-size: 16px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; color: rgb(0, 176, 80); font-family: 微软雅黑, " microsoft="" box-sizing:="" border-box="" overflow-wrap:="" break-word=""><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px; text-align: justify; caret-color:red">什么是类器官（Organoids）？</strong></span></h4><p style="margin: 0px 5px; padding: 12px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; vertical-align: inherit; line-height: 1.58824em; text-indent: 2em; font-family: 微软雅黑; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 16px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;">类器官归于三维（3D）细胞培育物，包含其代表器官的一些要害特性。类体外培育体系包含一个自我更新干细胞群，可分解为多个器官特异性的细胞类型，与对应的器官具有相似的空间安排并能够重现对应器官的部分功用，然后供给一个高度生理相关体系。成体干细胞的安排样本、单一成体干细胞或许经过多能干细胞的定向诱导分解都能够发生类器官。而细胞系异质性差，遗传信息丢掉，无法模仿安排器官体内的三维结构</time></span></time><span style="display: none; line-height: 0px; font-size: 16px;">‍</span><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="font-size: 16px;">；动物模</span></time></time><span style="display: none; line-height: 0px; font-size: 16px;">‍</span><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 16px; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;">型具有建模周期长，本钱高级问题。</time></span></time></p><p style="text-align: center"><img style="max-width: 800px; max-height: 300%; width: 541px; height: 213px;" src="uploadfiles/images/1429/20220518/185751_KtvqLO.png" title="640 (1).png" alt="640 (1).png" width="541" height="213" /></p><p style="margin-right: 5px; margin-bottom: 0px; margin-left: 5px; padding: 12px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; text-align: center; vertical-align: inherit; text-indent: 0em; line-height: 1.58824em; font-family: 微软雅黑; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; color: rgb(0, 176, 80); font-size: 16px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-indent: 0em; caret-color:red font-size: 15px; font-family: 微软雅黑, " microsoft="">类器官的使用远景</strong></span></p><p style="margin: 0px 5px; padding: 12px 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; vertical-align: inherit; line-height: 1.58824em; text-indent: 2em; font-family: 微软雅黑; box-sizing: border-box !important; overflow-wrap: break-word !important;"><span id="_<span class=" style="display: none; line-height: 0px;">‍</span><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></span></time><span id="_<span class=" style="display: none; line-height: 0px;">‍‍‍‍</span><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="font-size: 16px;">2013年，类器官技能被Science誉</span></time></time><span style="font-size: 16px;">‍</span><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="font-size: 16px;">为10 大科技发展，2017年，又被Nature Methods评为生命科学范畴的年度技能。类器</span></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="font-size: 16px;">官技能具有极高的</span></time></time><span style="font-size: 16px;">立异性，近年来一直是研讨热门，到现在为止已获得多项严重研讨范畴的打破‍，但其使用研讨现在仍然处于起步阶段，其作为一种东西，在广泛的使用研讨方面潜力巨大，包含发育生‍物学、疾病病理学、细胞生物学、再生机制、精准医疗以及药物毒性和药效实验。关于这些使用以及其他使用，类器官培育‍</span><span style="font-size: 16px;">完成了对现有2D培育办法和动物模型体系的高信息量的互补。此外，经过类器官繁衍的干细胞群替代受损或许患病的安排，类器官供给自体和同种异体细胞疗法的可行性，未来这一技能在再生医学范畴也具有巨大的潜力。</span><span id="_<span class=" style="display: none; line-height: 0px;">‍‍‍‍‍‍</span></p></section><section data-id="102702" data-tools="135编辑器" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; color: rgb(51, 51, 51); font-family: -apple-system, BlinkMacSystemFont, " helvetica="" sans="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" background-image:="" mmbiz.qpic.cn="" mmbiz_gif="" oirzt7ctxrnawwnlmkahx0eo9lf0tll2ebp4u1nailsyjrllgo3h3eox1vbuxbwzu6zys4cfje27bx6hw30hrg="" background-repeat:="" background-size:="" overflow-wrap:="" break-word=""><section style="margin: 10px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; text-align: center;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: inline-block;"><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; display: flex; justify-content: space-between; align-items: flex-end;"><section style="margin: 0px 0px 0px 2px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 40px;"></section><section style="margin: 0px 2px -10px 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; width: 17px;"></section></section><section style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; border-width: 1px; border-style: solid; border-color: rgb(120, 203, 150);"><section data-brushtype="text" hm_fix="351:883" style="margin: 0px; padding: 4px 2em; outline: 0px; max-width: 100%; box-sizing: border-box; overflow-wrap: break-word !important; background-color: rgb(240, 250, 246); font-size: 16px; color: rgb(51, 159, 101); letter-spacing: 1.5px; line-height: 2em;"><p style="margin: 0px 5px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; clear: both; min-height: 1em; vertical-align: inherit;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 18px;"><strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">研讨思路共享</strong></span></p></section></section></section></section></section><section data-role="paragraph" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box; font-family: -apple-system, BlinkMacSystemFont, " helvetica="" sans="" yahei="" font-size:="" letter-spacing:="" text-align:="" white-space:="" background-color:="" background-image:="" mmbiz.qpic.cn="" mmbiz_jpg="" oirzt7ctxrnawwnlmkahx0eo9lf0tll2jqazln7qra7pbyvciab3eouvo9w43cehxzrjsuehssiib5vey8hocnuq="" background-repeat:="" background-size:="" overflow-wrap:="" break-word=""><p style="color: rgb(51, 51, 51); margin-right: 5px; margin-left: 5px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; vertical-align: inherit; text-indent: 2em; box-sizing: border-box !important; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;">2022 年 1 月 19 日，由</span></time></time><time datetime="2022-01-19" style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: inherit; overflow-wrap: break-word !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important; font-size: 15px;">诺丁汉大学医学院癌症遗传学和干细胞组Abdolrahman S. Nateri教授团队在ONCOGENESIS(<strong style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important; overflow-wrap: break-word !important;">影响因子7.485</strong>)宣布了新研讨成果，题为《Anti-miR-135/SPOCK1 axis antagonizes the inflfluence ofmetabolism on drug response in intestinal/ colon tumourorganoids》。</span></time></time></p><p style="color: rgb(51, 51, 51); text-align: center;"><img style="max-width: 800px; max-height: 300%; width: 645px; height: 262px;" src="https://img76.chem17.com/9/20220223/63781207349699410023

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