怎么点评DSS诱导结肠炎模型是否成功

版块：机械制造类型：普通作者：化工产业技术分享查看：79 回复：0 获赞：0 时间：2022-05-18 17:32:20

怎么点评DSS诱导结肠炎模型是否成功

一、DSS 构建的UC模型特色

经过给予动物自在饮用不同浓度的DSS（MW:36000~50000）水溶液，依据用药时刻及用药周期可制成急性和缓慢两种结肠炎模型。该模型症状体现与人类UC极为类似，首要体现为腹泻、黏液样便、粪便潜血、肉眼血便、分量减轻、活动度削减，毛色变差等。

表1 DSS结肠炎模型组织学特征

DSS结肠炎模型类别	急性期结肠炎模型	缓慢期结肠炎模型
组织学改动	结肠充血、水肿、变短、变脆、分量长度比添加	结肠显着缩短
	呈现不同程度的结肠溃疡	粘膜增厚、淋巴结肿大
	黏膜水肿、杯状细胞缺失、隐窝肿胀损坏	杯状细胞缺失、隐窝缺失
	黏膜和黏膜基层呈现不同程度的炎症细胞滋润，上皮细胞损害	小部分动物呈现腺瘤性肉、肿瘤样改动

二、怎么点评造模是否成功？

1、疾病活泼指数评分（Disease Activity Index, DAI score）

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怎么点评DSS诱导结肠炎模型是否成功<p><br/></p><section powered-by="xiumi.us" style="margin: 0px 0px 20px; padding: 0px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 17px; line-height: 1; letter-spacing: 0px; text-align: center; visibility: visible; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; visibility: visible; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; visibility: visible; box-sizing: border-box !important;"><br style="overflow-wrap: normal !important; margin: 0px; padding: 0px;"/>一、DSS 构建的UC模型特色</strong></section></section></section><section powered-by="xiumi.us" style="margin: 0px; padding: 0px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; visibility: visible; box-sizing: border-box !important;"/></section></section><section powered-by="xiumi.us" style="margin: 0px; padding: 0px 8px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; line-height: 1.75; letter-spacing: 1px; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 15px; visibility: visible; overflow-wrap: break-word !important; box-sizing: border-box !important;">经过给予动物自在饮用不同浓度的DSS（MW:36000~50000）水溶液，依据用药时刻及用药周期可制成急性和缓慢两种结肠炎模型。该模型症状体现与人类UC极为类似，首要体现为腹泻、黏液样便、粪便潜血、肉眼血便、分量减轻、活动度削减，毛色变差等。</span></section><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"/></section><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; overflow-wrap: break-word !important; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 12px; overflow-wrap: break-word !important; box-sizing: border-box !important;">表1 DSS结肠炎模型组织学特征</span></strong></section><table cellspacing="0" width="894" align="left" style="max-width: 748px;"><tbody style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><tr class="firstRow" style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; height: 40px; box-sizing: border-box !important;"><td width="157" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 2px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(237, 125, 49); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; vertical-align: middle; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; color: rgb(255, 255, 255); font-size: 15px; box-sizing: border-box !important;">DSS结肠炎模型类别</span></strong></section></td><td width="179" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 2px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(237, 125, 49); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; vertical-align: middle; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; color: rgb(255, 255, 255); font-size: 15px; box-sizing: border-box !important;">急性期结肠炎模型</span></strong></section></td><td width="175" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: none; border-bottom: 2px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(237, 125, 49); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; vertical-align: middle; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; color: rgb(255, 255, 255); font-size: 15px; box-sizing: border-box !important;">缓慢期结肠炎模型</span></strong></section></td></tr><tr style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; height: 56px; box-sizing: border-box !important;"><td width="157" valign="center" rowspan="4" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(248, 203, 173); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">组织学改动</span></section></td><td width="179" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(248, 203, 173); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">结肠充血、水肿、变短、变脆、分量长度比添加</span></section></td><td width="175" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: none; border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(248, 203, 173); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">结肠显着缩短</span></section></td></tr><tr style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; height: 41px; box-sizing: border-box !important;"><td width="179" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(252, 228, 214); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">呈现不同程度的结肠溃疡</span></section></td><td width="175" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: none; border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(252, 228, 214); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">粘膜增厚、淋巴结肿大</span></section></td></tr><tr style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; height: 40px; box-sizing: border-box !important;"><td width="179" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(248, 203, 173); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">黏膜水肿、杯状细胞缺失、隐窝肿胀损坏</span></section></td><td width="175" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: none; border-bottom: 1px solid rgb(255, 255, 255); border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(248, 203, 173); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">杯状细胞缺失、隐窝缺失</span></section></td></tr><tr style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; height: 67px; box-sizing: border-box !important;"><td width="179" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border-top: none; border-right: 1px solid rgb(255, 255, 255); border-bottom: none; border-left: none; border-image: initial; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(252, 228, 214); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">黏膜和黏膜基层呈现不同程度的炎症细胞滋润，上皮细胞损害</span></section></td><td width="175" valign="center" style="margin: 0px; padding-right: 7px; padding-left: 7px; border: none; outline: 0px; word-break: break-all; max-width: 100%; background: rgb(252, 228, 214); overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; vertical-align: middle; box-sizing: border-box !important;"><span style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; font-family: 微软雅黑; outline: 0px; max-width: 100%; font-size: 13px; box-sizing: border-box !important;">小部分动物呈现腺瘤性</span>肉、肿瘤样改动</section></td></tr></tbody></table><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 15px; overflow-wrap: break-word !important; box-sizing: border-box !important;"></span><br style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"/></section><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"/></section><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 15px; overflow-wrap: break-word !important; box-sizing: border-box !important;"> </span></section></section><section style="margin: 10px 8px -30px; padding: 0px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; text-align: center; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; display: inline-block; width: 55px; height: 55px; vertical-align: top; overflow: hidden; background-color: rgb(255, 150, 0); box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><svg viewbox="0 0 1 1" style="float:left;line-height:0;width:0;vertical-align:top;"></svg></section></section></section><section powered-by="xiumi.us" style="margin: 0px 0px 20px; padding: 0px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 17px; line-height: 1; letter-spacing: 0px; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; text-align: center; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;">二、怎么点评造模是否成功？</strong></section></section></section><section powered-by="xiumi.us" style="margin: 0px; padding: 0px 8px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; line-height: 1.75; letter-spacing: 1px; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: border-box !important;"><br style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"/></section></section><section style="margin: 10px 8px; padding: 0px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; justify-content: flex-start; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; display: inline-block; width: auto; vertical-align: top; min-width: 10%; height: auto; border-bottom: 17px solid rgb(255, 230, 199); border-bottom-right-radius: 0px; box-sizing: border-box !important;"><section powered-by="xiumi.us" style="overflow-wrap: break-word !important; margin: 0px 0px -8px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;"><section style="overflow-wrap: break-word !important; margin: 0px; padding: 0px 5px; outline: 0px; max-width: 100%; letter-spacing: 0px; line-height: 1; font-size: 18px; color: rgb(255, 129, 36); box-sizing: border-box !important;"><p style="margin-top: 0px; margin-bottom: 0px; padding: 0px; outline: 0px; max-width: 100%; clear: both; min-height: 1em; overflow-wrap: break-word !important; box-sizing: border-box !important;"><span style="margin: 0px; padding: 0px; outline: 0px; max-width: 100%; font-size: 15px; overflow-wrap: break-word !important; box-sizing: border-box !important;"><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;">1、疾病活泼指数评分（Disease Activity Index, DAI score</strong></span><strong style="overflow-wrap: break-word !important; margin: 0px; padding: 0px; outline: 0px; max-width: 100%; box-sizing: border-box !important;">）</strong></p></section></section></section></section><section powered-by="xiumi.us" style="margin: 0px; padding: 0px 8px; color: rgb(41, 41, 41); font-family: "times new roman", SimHei; font-size: medium; white-space: normal; outline: 0px; max-width: 100%; line-height: 1.75; letter-spacing: 1px; overflow-wrap: break-word !important; box-sizing: border-box !important;"><section style="margin: 0px 8px; padding: 0px; outline: 0px; max-width: 100%; overflow-wrap: break-word !important; box-sizing: bor

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